{"id":1413,"date":"2013-08-08T10:36:15","date_gmt":"2013-08-08T10:36:15","guid":{"rendered":"http:\/\/biosi.subsite.cf.ac.uk\/biosi\/kille-morgan\/?p=1413"},"modified":"2015-06-19T09:51:41","modified_gmt":"2015-06-19T09:51:41","slug":"publication-a-mechanism-for-epithelial-mesenchymal-transition-and-anoikis-resistance-in-breast-cancer-triggered-by-zinc-channel-zip6-and-signal-transducer-and-activator-of-transcription-3-stat3","status":"publish","type":"post","link":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/2013\/08\/08\/publication-a-mechanism-for-epithelial-mesenchymal-transition-and-anoikis-resistance-in-breast-cancer-triggered-by-zinc-channel-zip6-and-signal-transducer-and-activator-of-transcription-3-stat3\/","title":{"rendered":"Publication: A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer Triggered by Zinc Channel ZIP6 and Signal Transducer and Activator of Transcription 3 (STAT3)"},"content":{"rendered":"

Professor Kille<\/a>\u00a0is part of a collaboration in Cardiff that has published their latest findings on the mechanism involved with zinc channels in breast cancer.<\/p>\n

The advance publication is available here<\/a><\/p>\n

A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer Triggered by Zinc Channel ZIP6 and Signal Transducer and Activator of Transcription 3 (STAT3)<\/strong><\/p>\n

Christer Hogstrand, Peter Kille, Margaret Leigh Ackland, Stephen Hiscox and Kathryn M Taylor. Cardiff University, CARDIFF, United Kingdom.<\/em><\/p>\n

Genes involved in normal developmental processes attract attention as mediators of tumour progression as they facilitate migration of tumour cells. Epithelial-mesenchymal transition (EMT), an essential part of embryonic development, tissue remodelling and wound repair, is crucial for tumour metastasis. Previously zinc transporter ZIP6 (SLC39A6, LIV-1) was linked to EMT in zebrafish gastrulation through a STAT3 mechanism resulting in nuclear localisation of transcription factor Snail. Here we show that zinc transporter ZIP6 is transcriptionally induced by STAT3 and unprecedented among zinc transporters is activated by N-terminal cleavage which triggers ZIP6 plasma membrane location and zinc influx. This zinc influx inactivates GSK-3\u03b2, either indirectly or directly via AKT or GSK-3\u03b2, respectively, resulting in activation of Snail, which remains in the nucleus and acts as a transcriptional repressor of E-cadherin, CDH1, causing cell rounding and detachment. This was mirrored by ZIP6-transfected cells which underwent EMT, detached from monolayers and exhibited resistance to anoikis by their ability to continue proliferating even after detachment. Our results indicate a causative role for ZIP6 in cell motility and migration, providing ZIP6 as a new target for prediction of clinical cancer spread and also suggesting a ZIP6-dependant mechanism of tumour metastasis.<\/span><\/p>\n

\n

doi:10.1042\/BJ20130483
\nReceived 5 April 2013\/15 July 2013; Accepted 7 August 2013
\nPublished as Immediate Publication 7 August 2013<\/p>\n","protected":false},"excerpt":{"rendered":"

Professor Kille\u00a0is part of a collaboration in Cardiff that has published their latest findings on the mechanism involved with zinc channels in breast cancer. The advance publication is available here A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer Triggered by Zinc Channel ZIP6 and Signal Transducer and Activator of Transcription 3 (STAT3)<\/p>\n","protected":false},"author":3463,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Publication: A Mechanism for Epithelial-Mesenchymal Transition and Anoikis Resistance in Breast Cancer....","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[11],"tags":[],"class_list":["post-1413","post","type-post","status-publish","format-standard","hentry","category-publications"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p6t6rP-mN","meta_box":[],"_links":{"self":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/1413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/users\/3463"}],"replies":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/comments?post=1413"}],"version-history":[{"count":1,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/1413\/revisions"}],"predecessor-version":[{"id":2598,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/1413\/revisions\/2598"}],"wp:attachment":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/media?parent=1413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/categories?post=1413"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/tags?post=1413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}