{"id":2240,"date":"2013-12-15T00:24:20","date_gmt":"2013-12-15T00:24:20","guid":{"rendered":"http:\/\/biosi.subsite.cf.ac.uk\/biosi\/kille-morgan\/hot-paper-interesting-perspective-about-double-meaning-in-dna-code\/"},"modified":"2015-06-19T09:51:25","modified_gmt":"2015-06-19T09:51:25","slug":"hot-paper-interesting-perspective-about-double-meaning-in-dna-code-2","status":"publish","type":"post","link":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/2013\/12\/15\/hot-paper-interesting-perspective-about-double-meaning-in-dna-code-2\/","title":{"rendered":"Hot paper!!! Interesting perspective about double meaning in DNA code?"},"content":{"rendered":"

\n<\/h1>\n

\n<\/h1>\n

The Hidden Codes That Shape Protein Evolution<\/h1>\n
    \n
  1. Robert J. Weatheritt<\/a>,<\/li>\n
  2. M. Madan Babu<\/a><\/li>\n<\/ol>\n

    +<\/a> Author Affiliations<\/p>\n

      \n
    1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.<\/li>\n<\/ol>\n
        \n
      1. E-mail: rweather; madanm<\/li>\n<\/ol>\n

        Despite redundancy in the genetic code (1<\/em>), the choice of codons used is highly biased in some proteins, suggesting that additional constraints operate in certain protein-coding regions of the genome. This suggests that the preference for particular codons, and therefore amino acids in specific regions of the protein, is often determined by factors unrelated to protein structure or function (2<\/em>, 3<\/em>). On page 1367 in this issue, Stergachis et al.<\/em> (4<\/em>) reveal that transcription factors bind within protein-coding regions (in addition to nearby noncoding regions) in a large number of human genes. Thus, a transcription factor \u201cbinding code\u201d may influence codon choice and, consequently, protein evolution. This \u201cbinding\u201d code joins other \u201cregulatory\u201d codes that govern chromatin organization (3<\/em>), enhancers (5<\/em>, 6<\/em>), mRNA structure (7<\/em>), mRNA splicing (3<\/em>), microRNA target sites (6<\/em>, 8<\/em>), translational efficiency (9<\/em>), and cotranslational folding (10<\/em>), all of which have been proposed to constrain codon choice, and thus protein evolution (see the figure).<\/p>\n

        PAPER<\/a> Here<\/p>\n

        Lu\u00eds Cunha (Research Associate)<\/strong><\/p>\n

        Cardiff University, Cardiff School of Biosciences, Room 0.39, Main Building, Museum Avenue, Cardiff, CF10 3AT, United Kingdom
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        The Hidden Codes That Shape Protein Evolution Robert J. Weatheritt, M. Madan Babu + Author Affiliations MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. E-mail: rweather; madanm Despite redundancy in the genetic code (1), the choice of codons used is highly biased in some proteins, suggesting that additional constraints operate in<\/p>\n","protected":false},"author":3463,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8],"tags":[],"class_list":["post-2240","post","type-post","status-publish","format-standard","hentry","category-hot-papers"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p6t6rP-A8","meta_box":[],"_links":{"self":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/2240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/users\/3463"}],"replies":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/comments?post=2240"}],"version-history":[{"count":1,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/2240\/revisions"}],"predecessor-version":[{"id":2580,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/2240\/revisions\/2580"}],"wp:attachment":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/media?parent=2240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/categories?post=2240"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/tags?post=2240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}