{"id":2242,"date":"2013-12-23T12:12:14","date_gmt":"2013-12-23T12:12:14","guid":{"rendered":"http:\/\/biosi.subsite.cf.ac.uk\/biosi\/kille-morgan\/neanderthal-introgression-at-chromosome-3p21-31-was-under-positive-natural-selection-in-east-asians\/"},"modified":"2015-06-19T09:50:11","modified_gmt":"2015-06-19T09:50:11","slug":"neanderthal-introgression-at-chromosome-3p21-31-was-under-positive-natural-selection-in-east-asians-2","status":"publish","type":"post","link":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/2013\/12\/23\/neanderthal-introgression-at-chromosome-3p21-31-was-under-positive-natural-selection-in-east-asians-2\/","title":{"rendered":"Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians"},"content":{"rendered":"<p><a href=\"http:\/\/mbe.oxfordjournals.org\/content\/early\/2013\/12\/13\/molbev.mst260.abstract.html?papetoc\">http:\/\/mbe.oxfordjournals.org\/content\/early\/2013\/12\/13\/molbev.mst260.abstract.html?papetoc<\/a><br \/>\n<strong>Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians<\/strong><\/p>\n<p>Studies of the Neanderthal and Denisovan genomes demonstrate archaic hominin introgression in Eurasians. Here we present evidence of Neanderthal introgression within the chromosome 3p21.31 region, occurring with a high frequency in East Asians (ranging from 49.4% to 66.5%) and at a low frequency in Europeans. <\/p>\n<div><a href=\"http:\/\/blog.csba.org\/viagra-from-canadian-pharmacy\/\" title=\"viagra from canadian pharmacy\">viagra from canadian pharmacy<\/a><\/div>\n<p> We also detected a signal of strong positive selection in this region only in East Asians. Our data indicate that likely candidate targets of selection include rs12488302-T and its associated alleles\u2014among which four are non-synonymous, including rs35455589-G in <em>HYAL2<\/em>, a gene related to the cellular response to ultraviolet-B irradiation. Furthermore, suggestive evidence supports latitude-dependent selection, implicating a role of ultraviolet-B. Interestingly, the distribution of rs35455589-G suggests that this allele was lost during the exodus of ancestors of modern Eurasians from Africa, and reintroduced to Eurasians from Neanderthals.<\/p>\n<p>Professor Peter Kille,<\/p>\n<p>Cardiff School of Biosciences (BIOSI 1),<br \/>\nCardiff University,<br \/>\nMain Building,<br \/>\nCardiff<br \/>\nCF10 3AT<\/p>\n<p>Tel: +44 (0)29 20874507<br \/>\nMobile: 07870655403<br \/>\nEmail: Kille@cardiff.ac.uk<\/p>\n<p><a href=\"http:\/\/biosi.subsite.cf.ac.uk\/biosi\/kille-morgan\/\">http:\/\/biosi.subsite.cf.ac.uk\/biosi\/kille-morgan\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>http:\/\/mbe.oxfordjournals.org\/content\/early\/2013\/12\/13\/molbev.mst260.abstract.html?papetoc Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians Studies of the Neanderthal and Denisovan genomes demonstrate archaic hominin introgression in Eurasians. Here we present evidence of Neanderthal introgression within the chromosome 3p21.31 region, occurring with a high frequency in East Asians (ranging from 49.4% to 66.5%) and at a<\/p>\n","protected":false},"author":3463,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[9],"tags":[],"class_list":["post-2242","post","type-post","status-publish","format-standard","hentry","category-hot-methods"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p6t6rP-Aa","meta_box":[],"_links":{"self":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/2242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/users\/3463"}],"replies":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/comments?post=2242"}],"version-history":[{"count":1,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/2242\/revisions"}],"predecessor-version":[{"id":2574,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/posts\/2242\/revisions\/2574"}],"wp:attachment":[{"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/media?parent=2242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/categories?post=2242"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/kille-morgan\/wp-json\/wp\/v2\/tags?post=2242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}