{"id":101,"date":"2013-11-07T14:25:00","date_gmt":"2013-11-07T14:25:00","guid":{"rendered":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/?page_id=101"},"modified":"2021-12-02T14:42:43","modified_gmt":"2021-12-02T14:42:43","slug":"riboflavinuva-cross-linking","status":"publish","type":"page","link":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/riboflavinuva-cross-linking\/","title":{"rendered":"RIBOFLAVIN\/UVA CROSS-LINKING"},"content":{"rendered":"<p><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/historical-background\/\"><strong><span style=\"color: #000000\">HISTORICAL BACKGROUND<\/span><\/strong><\/a><\/p>\n<p style=\"text-align: justify\">The potential of ultraviolet-A light (UVA)\u00a0to cross-link tissues in the presence of the non-toxic photosensitising agent riboflavin had been known for some time, but it was not until\u00a01998 that a group from Dresden suggested it as a potential therapeutic treatment to strengthen the corneal stroma&#8230;.<a href=\"https:\/\/sites.cardiff.ac.uk\/ukcxl\/what-is-cross-linking\/\"><strong>Read more<\/strong><\/a><\/p>\n<p style=\"text-align: justify\"><span style=\"color: #000000\"><strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/cross-linking-scenarios\/\"><span style=\"color: #000000\">MECHANISM OF CROSS-LINKING<\/span><\/a><\/strong><\/span><\/p>\n<p style=\"text-align: justify\">At present, it is still not known exactly what the nature of the cross-links is, and precisely where they occur within the extracellular matrix.\u00a0Theoretically cross-linking could occur not just between collagen molecules but also between collagens and proteoglycan core proteins&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/cross-linking-scenarios\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/standard-procedure\/\"><strong><span style=\"color: #000000\">DRESDEN PROTOCOL<\/span><\/strong><\/a><\/p>\n<p style=\"text-align: justify\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/KXL-procedure.png\"><img decoding=\"async\" class=\"wp-image-9 alignright\" src=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/KXL-procedure.png\" alt=\"CXL procedure\" width=\"118.1\" height=\"100\" srcset=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/KXL-procedure.png 382w, http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/KXL-procedure-300x253.png 300w\" sizes=\"(max-width: 382px) 100vw, 382px\" \/><\/a><\/p>\n<p style=\"text-align: justify\">The original cross-linking procedure (commonly referred to as the \u2018Dresden protocol\u2019)\u00a0involved\u00a0anaesthetising the eye (for example with proxymetacainhydrochloride 0.5% drops), removing the central 8-10mm of the epithelium and applying a riboflavin solution&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/standard-procedure\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\"><a style=\"line-height: 1.714285714;font-size: 1rem\" href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/trans-epithelial-protocol\/\"><strong><span style=\"color: #000000\">TRANS-EPITHELIAL PROCEDURES<\/span><\/strong><\/a><\/p>\n<p style=\"text-align: justify\">In order to overcome the problems of postoperative discomfort, potential for delayed epithelial healing,\u00a0infection,\u00a0stromal haze,\u00a0and corneal melting sometimes associated with the standard cross-linking procedure,\u00a0researchers are investigating modifications to the procedure which\u00a0will allow the same stiffening effect to occur in the corneal stroma without the need for epithelial removal&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/trans-epithelial-protocol\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/accelerated-cross-linking\/\"><strong><span style=\"color: #000000\">ACCELERATED CROSS-LINKING<\/span><\/strong><\/a><\/p>\n<p style=\"text-align: justify\">With the aim of reducing treatment time and increasing the throughput of patients, investigators are now considering the use of higher illumination intensities in the cross-linking procedure&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/accelerated-cross-linking\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/modified-protocol-for-the-treatment-of-thin-corneas\/\"><strong><span style=\"color: #000000\">MODIFIED PROTOCOL FOR THE TREATMENT OF THIN CORNEAS<\/span><\/strong><\/a><\/p>\n<p style=\"text-align: justify\">Overcoming the contra-indication of treating corneas with a thickness bordering on 400\u03bcm&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/modified-protocol-for-the-treatment-of-thin-corneas\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\">\n","protected":false},"excerpt":{"rendered":"<p>HISTORICAL BACKGROUND The potential of ultraviolet-A light (UVA)\u00a0to cross-link tissues in the presence of the non-toxic photosensitising agent riboflavin had been known for some time, but it was not until\u00a01998 that a group from Dresden suggested it as a potential therapeutic treatment to strengthen the corneal stroma&#8230;.Read more MECHANISM OF CROSS-LINKING At present, it is [&hellip;]<\/p>\n","protected":false},"author":826,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-101","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P3RmFt-1D","jetpack_sharing_enabled":true,"meta_box":[],"_links":{"self":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/users\/826"}],"replies":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/comments?post=101"}],"version-history":[{"count":24,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/101\/revisions"}],"predecessor-version":[{"id":1683,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/101\/revisions\/1683"}],"wp:attachment":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/media?parent=101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}