{"id":16,"date":"2013-08-29T09:34:37","date_gmt":"2013-08-29T09:34:37","guid":{"rendered":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/?page_id=16"},"modified":"2021-12-02T14:33:51","modified_gmt":"2021-12-02T14:33:51","slug":"what-is-cross-linking","status":"publish","type":"page","link":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/what-is-cross-linking\/","title":{"rendered":"CORNEAL CROSS-LINKING"},"content":{"rendered":"<div>\n<p style=\"text-align: justify\">The potential of ultraviolet-A light (UVA) to cross-link tissues in the presence of the non-toxic photosensitising agent riboflavin had been known for some time, but it was not until 1998 that a group from Dresden suggested it as a potential therapeutic treatment to strengthen the corneal stroma.\u00a0 The concept was based on the observation that naturally occurring protein cross-linking, which accelerates with age, strengthens and stiffens the cornea. It was suggested that artificial cross-linking may have a similar effect, and be particularly useful in the management of conditions where the strength of the cornea is compromised, such as <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/causes\/\">keratoconus<\/a> or <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/symptoms\/\">post-LASIK ectasia<\/a>.\u00a0Over recent years, <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/riboflavinuva-cross-linking\/\">riboflavin\/UVA corneal cross-linking<\/a> has been widely adopted, refined and applied in a range of <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/what-is-keratoconus\/\">corneal surgeries and pathologies.<\/a><\/p>\n<p style=\"text-align: justify\">Although <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/riboflavinuva-cross-linking\/\">riboflavin\/UVA cross-linking<\/a> is now considered to be the standard care treatment for progressive keratoconus and post-LASIK ectasia, the potential of other collagen cross-linking therapies such as <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/rose-bengalgreen-light\/\">Rose Bengal with green light<\/a>,\u00a0<a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/bacteriochlorophyll-derivative-wst11nir\/\">bacteriochlorophyll derivative WST11 with near infrared light<\/a>, <a href=\"https:\/\/sites.cardiff.ac.uk\/ukcxl\/genipin\/\">genipin<\/a> and <a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/aliphatic-beta-nitro-alcohols\/\">aliphatic beta-nitro alcohols<\/a> are also being investigated.<\/p>\n<p style=\"text-align: center\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/cropped-KXL-procedure.png\"><img decoding=\"async\" class=\" wp-image-200 aligncenter\" src=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/cropped-KXL-procedure-300x77.png\" alt=\"cropped-KXL-procedure.png\" width=\"346.7\" height=\"89\" srcset=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/cropped-KXL-procedure-300x77.png 300w, http:\/\/sites.cardiff.ac.uk\/ukcxl\/files\/2013\/08\/cropped-KXL-procedure.png 382w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>Last updated: March 2021<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The potential of ultraviolet-A light (UVA) to cross-link tissues in the presence of the non-toxic photosensitising agent riboflavin had been known for some time, but it was not until 1998 that a group from Dresden suggested it as a potential therapeutic treatment to strengthen the corneal stroma.\u00a0 The concept was based on the observation that [&hellip;]<\/p>\n","protected":false},"author":822,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P3RmFt-g","jetpack_sharing_enabled":true,"meta_box":[],"_links":{"self":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/16","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/users\/822"}],"replies":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/comments?post=16"}],"version-history":[{"count":25,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/16\/revisions"}],"predecessor-version":[{"id":1682,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/16\/revisions\/1682"}],"wp:attachment":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/media?parent=16"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}