{"id":609,"date":"2014-03-07T11:00:55","date_gmt":"2014-03-07T11:00:55","guid":{"rendered":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/?page_id=609"},"modified":"2015-07-23T14:06:59","modified_gmt":"2015-07-23T14:06:59","slug":"protocols","status":"publish","type":"page","link":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/protocols\/","title":{"rendered":"PROTOCOLS"},"content":{"rendered":"<p><span style=\"color: #003366\"><span style=\"color: #003366\"><strong><span style=\"color: #000000\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/standard-procedure\/\"><span style=\"color: #000000\">STANDARD\u00a0PROTOCOL<\/span><\/a><\/span><\/strong><\/span><\/span><\/p>\n<p style=\"text-align: justify\">The original cross-linking procedure (often referred to as the \u2018Dresden protocol\u2019) involved\u00a0anaesthetising the eye (for example with proxymetacainhydrochloride 0.5% drops), removing the central 8-10 mm of the epithelium and applying a riboflavin solution (0.1% riboflavin-5-phosphate and 20% dextran T-500) to the corneal surface 30 minutes before irradiation and at 5 minutes intervals during the course of a 30 minute exposure to 370 nm UVA with an irradiance of 3 mWcm<sup>-2<\/sup>\u00a0&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/standard-procedure\/\">Read more<\/a><\/strong><\/p>\n<p><strong><span style=\"color: #000000\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/trans-epithelial-protocol\/\"><span style=\"color: #000000\">TRANS-EPITHELIAL PROCEDURES<\/span><\/a><\/span><\/strong><\/p>\n<p style=\"text-align: justify\">In order to overcome the problems of postoperative discomfort, potential for delayed epithelial healing,\u00a0infection,\u00a0stromal haze,\u00a0and corneal melting sometimes associated with the standard cross-linking procedure,\u00a0researchers are investigating modifications to the procedure that will allow the same stiffening effect to occur in the corneal stroma without the need for epithelial removal&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/trans-epithelial-protocol\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\"><strong><span style=\"color: #000000\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/accelerated-cross-linking\/\"><span style=\"color: #000000\">ACCELERATED CROSS-LINKING<\/span><\/a><\/span><\/strong><\/p>\n<p style=\"text-align: justify\">With the aim of reducing treatment time and increasing the throughput of patients, investigators are now considering the use of higher illumination intensities in the CXL procedure&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/accelerated-cross-linking\/\">Read more<\/a><\/strong><\/p>\n<p style=\"text-align: justify\"><strong><span style=\"color: #000000\"><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/modified-protocol-for-the-treatment-of-thin-corneas\/\"><span style=\"color: #000000\">MODIFIED PROTOCOL FOR THE TREATMENT OF THIN CORNEAS<\/span><\/a><\/span><\/strong><\/p>\n<p style=\"text-align: justify\">In order to overcome the contra-indication of treating corneas with a thickness bordering on 400\u03bcm,\u00a0pachymetry-guided epithelial debridement was developed &#8211; a treatment modification in which the epithelium is only removed from regions of the cornea with a thickness in excess of 400\u03bcm&#8230;.<strong><a href=\"http:\/\/sites.cardiff.ac.uk\/ukcxl\/modified-protocol-for-the-treatment-of-thin-corneas\/\">Read more<\/a><\/strong><\/p>\n<h1><\/h1>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STANDARD\u00a0PROTOCOL The original cross-linking procedure (often referred to as the \u2018Dresden protocol\u2019) involved\u00a0anaesthetising the eye (for example with proxymetacainhydrochloride 0.5% drops), removing the central 8-10 mm of the epithelium and applying a riboflavin solution (0.1% riboflavin-5-phosphate and 20% dextran T-500) to the corneal surface 30 minutes before irradiation and at 5 minutes intervals during the [&hellip;]<\/p>\n","protected":false},"author":979,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-609","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P3RmFt-9P","jetpack_sharing_enabled":true,"meta_box":[],"_links":{"self":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/users\/979"}],"replies":[{"embeddable":true,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/comments?post=609"}],"version-history":[{"count":4,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/609\/revisions"}],"predecessor-version":[{"id":1007,"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/pages\/609\/revisions\/1007"}],"wp:attachment":[{"href":"http:\/\/sites.cardiff.ac.uk\/ukcxl\/wp-json\/wp\/v2\/media?parent=609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}