Clinically Informed Biomaterials – Chemistry and Engineering
14/11/2017, 11:30 - 12:45
Cardiff University’s Pro Vice-Chancellor for International & Europe, Professor Nora de Leeuw, invites you to a guest lecture delivered by Professor Mark W Grinstaff, Distinguished Professor of Translational Research and a Professor at the Departments of Biomedical Engineering, Chemistry, and Medicine at Boston University.
Title: Clinically Informed Biomaterials – Chemistry and Engineering
“As an academic scientist and engineer working in interdisciplinary research, I ask questions all the time – from the most basic (how do we design small molecules to enable the synthesis of advanced materials?) to the most translational (how do we take a laboratory discovery to the clinic?). Through this process, I challenge my students and fellows to determine and elucidate the underlying chemistry and engineering principles. In this lecture, I will share our stories and successes in translating ideas from the laboratory to the preclinical and clinic setting. I begin with synthesis of unique dendrimers and dendritic-based hydrogels as adhesives for wound management, followed by the synthesis and use of polyglycerol carbonates for controlled drug delivery to prevent lung cancer recurrence, and, finally, ROMP to prepare large molecular weight polyanions as lubricants for cartilage surfaces and the potential treatment for osteoarthritis. In each section, I will highlight the design requirements, the synthetic routes and characterization data, and the performance outcomes in in vitro and in vivo experiments.”
Mark W. Grinstaff is a Distinguished Professor of Translational Research and a Professor of Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials at Boston University. Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark’s awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher-Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is a co-founder of five companies and his innovative ideas and his efforts have also led to one new FDA approved pharmaceutical (AbraxaneTM) and four medical device products (OcuSeal® and Adherus Surgical Sealants®) that improve clinical care for hundreds of thousands of people. His current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair.
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