NeEstimator v2: re-implementation of software for the estimation of contemporary effective population size ( Ne) from genetic data

Posted on 23 December 2013 by Pete

http://onlinelibrary.wiley.com/doi/10.1111/1755-0998.12157/full NeEstimator v2: re-implementation of software for the estimation of contemporary effective population size (Ne) from genetic data neestimator v2 is a completely revised and updated implementation of software that produces estimates of contemporary effective population size, using several different methods and a single input file. neestimator v2 includes three single-sample estimators (updated versions of
Read more

Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians

Posted on 23 December 2013 by Pete

http://mbe.oxfordjournals.org/content/early/2013/12/13/molbev.mst260.abstract.html?papetoc Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians Studies of the Neanderthal and Denisovan genomes demonstrate archaic hominin introgression in Eurasians. Here we present evidence of Neanderthal introgression within the chromosome 3p21.31 region, occurring with a high frequency in East Asians (ranging from 49.4% to 66.5%) and at a
Read more

Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians

Posted on 23 December 2013 by Pete

http://mbe.oxfordjournals.org/content/early/2013/12/13/molbev.mst260.abstract.html?papetoc Neanderthal Introgression at Chromosome 3p21.31 was Under Positive Natural Selection in East Asians Studies of the Neanderthal and Denisovan genomes demonstrate archaic hominin introgression in Eurasians. Here we present evidence of Neanderthal introgression within the chromosome 3p21.31 region, occurring with a high frequency in East Asians (ranging from 49.4% to 66.5%) and at a
Read more

Quantitative genetic study of the adaptive process

Posted on 23 December 2013 by Pete

http://www.nature.com/hdy/journal/v112/n1/abs/hdy201342a.html?WT.ec_id=HDY-201401 Quantitative genetic study of the adaptive process The additive genetic variance with respect to absolute fitness, VA(W), divided by mean absolute fitness, sets the rate of ongoing adaptation. Fisher’s key insight yielding this quantitative prediction of adaptive evolution, known as the Fundamental Theorem of Natural Selection, is well appreciated by evolutionists. Nevertheless, extremely scant
Read more

Post-GWAS: where next? More samples, more SNPs or more biology?

Posted on 23 December 2013 by Pete

http://www.nature.com/hdy/journal/v112/n1/abs/hdy201352a.html?WT.ec_id=HDY-201401 Post-GWAS: where next? More samples, more SNPs or more biology? The power of genome-wide association studies (GWAS) rests on several foundations: (i) there is a significant amount of additive genetic variation, (ii) individual causal polymorphisms often have sizable effects and (iii) they segregate at moderate-to-intermediate frequencies, or will be effectively ‘tagged’ by polymorphisms that
Read more

Hot Paper! Phylowood: interactive web-based animations of biogeographic and phylogeographic histories

Posted on 23 December 2013 by Pete

http://bioinformatics.oxfordjournals.org/content/30/1/123.abstract.html?etoc Phylowood: interactive web-based animations of biogeographic and phylogeographic histories Summary: Phylowood is a web service that uses JavaScript to generate in-browser animations of biogeographic and phylogeographic histories from annotated phylogenetic input. The animations are interactive, allowing the user to adjust spatial and temporal resolution, and highlight phylogenetic lineages of interest. Availability and implementation: All
Read more